期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 1, 页码 58-63出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix562
关键词
Ebola virus; hemorrhagic fever; humanized mice; Reston virus; NSG-SGM3
资金
- Division of Intramural Research of the National Institutes of Health, National Institute of Allergy and Infectious Diseases
- National Institutes of Health Loan Repayment Award
Both Ebola virus (EBOV) and Reston virus (RESTV) cause disease in nonhuman primates, yet only EBOV causes disease in humans. To investigate differences in viral pathogenicity, humanized mice (hu-NSG-SGM3) were inoculated with EBOV or RESTV. Consistent with differences in disease in human infection, pronounced weight loss and markers of hepatic damage and disease were observed exclusively in EBOV-infected mice. These abnormalities were associated with significantly higher EBOV replication in the liver but not in the spleen, suggesting that in this model, efficiency of viral replication in select tissues early in infection may contribute to differences in viral pathogenicity.
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