期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 1, 页码 82-92出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix524
关键词
Colombia; Klebsiella pneumoniae; KPC
资金
- Veterans Affairs Office Research and Development [1I01BX001974]
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R21AI114508, R01AI100560, R01AI063517, R01AI072219, K24-AI114818, R01-AI093749, R21-AI114961, R21/R33 AI121519]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [K24AI121296] Funding Source: NIH RePORTER
Background. Carbapenem resistance is a critical healthcare challenge worldwide. Particularly concerning is the widespread dissemination of Klebsiella pneumoniae carbapenemase (KPC). Klebsiella pneumoniae harboring bla(KPC) (KPC-Kpn) is endemic in many areas including the United States, where the epidemic was primarily mediated by the clonal dissemination of Kpn ST258. We postulated that the spread of bla(KPC) in other regions occurs by different and more complex mechanisms. To test this, we investigated the evolution and dynamics of spread of KPC-Kpn in Colombia, where KPC became rapidly endemic after emerging in 2005. Methods. We sequenced the genomes of 133 clinical isolates recovered from 24 tertiary care hospitals located in 10 cities throughout Colombia, between 2002 (before the emergence of KPC-Kpn) and 2014. Phylogenetic reconstructions and evolutionary mapping were performed to determine temporal and genetic associations between the isolates. Results. Our results indicate that the start of the epidemic was driven by horizontal dissemination of mobile genetic elements carrying bla(KPC-2), followed by the introduction and subsequent spread of clonal group 258 (CG258) isolates containing bla(KPC-3). Conclusions. The combination of 2 evolutionary mechanisms of KPC-Kpn within a challenged health system of a developing country created the perfect storm for sustained endemicity of these multidrug-resistant organisms in Colombia.
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