期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 2, 页码 257-262出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix512
关键词
IFITM3; influenza A virus; rs12252
资金
- Medical Research Council, UK
- National Natural Science Foundation of China [81271842, 81228020, 81320108017]
- Beijing Natural Science Foundation [7132098]
- National S and T Major Project for Infectious Diseases Control [2012ZX10001006-001-008, 2013ZX10001004-001-002]
- Beijing Municipal Administration of Hospitals [XMLX201411]
- Beijing Key Laboratory [BZ0373]
- Capital Health Development [TG-2015-19]
- Medical Research Council [1612663, G1001046, MR/L018942/1, G0600520] Funding Source: researchfish
- MRC [G0600520, MR/L018942/1, G1001046] Funding Source: UKRI
Interferon-induced transmembrane 3 (IFITM3) is known to restrict the entry of a range of enveloped viruses. The single nucleotide polymorphism rs12252-C within IFITM3 has been shown to be associated with severe influenza A virus infection. It has been suggested that rs12252-C results in expression of a truncated IFITM3 protein lacking the first 21 amino acids. By performing high-throughput RNA sequencing on primary dendritic cells and peripheral blood mononuclear cells isolated from pandemic H1N1 influenza and human immunodeficiency virus-1 (HIV-1) infected patients we show that full-length IFITM3 mRNA is dominantly expressed (> 99%) across all rs12252 genotypes. Full-length IFITM3 protein can be detected in all genotypes.
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