期刊
JOURNAL OF INFECTIOUS DISEASES
卷 215, 期 6, 页码 975-983出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix062
关键词
Staphylococcus aureus; biofilm; antimicrobial peptides (AMPs); catheter lock solution (CLS)
资金
- Irish Health Research Board [HRA-POR-2012-52]
- Healthcare Infection Society
- Science Foundation Ireland [06/RFP/CHO024/EC07]
- Science Foundation Ireland (SFI) [06/RFP/CHO024/EC07, 06/RFP/CHO024] Funding Source: Science Foundation Ireland (SFI)
- Health Research Board (HRB) [HRA-POR-2012-52] Funding Source: Health Research Board (HRB)
Here, we demonstrate that antimicrobial peptides (AMPs) are an effective antibiofilm treatment when applied as catheter lock solutions (CLSs) against S. aureus biofilm infections. The activity of synthetic AMPs (Bac8c, HB43, P18, Omiganan, WMR, Ranalexin, and Polyphemusin) was measured against early and mature biofilms produced by methicillin-resistant S. aureus and methicillin-susceptible S. aureus isolates from patients with device-related infections grown under in vivo-relevant biofilm conditions. The cytotoxic and hemolytic activities of the AMPs against human cells and their immunomodulatory potential in human blood were also characterized. The D-Bac8c2,5Leu variant emerged as the most effective AMP during in vitro studies and was also highly effective in eradicating S. aureus biofilm infection when used in a CLS rat central venous catheter infection model. These data support the potential use of D-Bac8c2,5Leu, alone or in combination with other AMPs, in the treatment of S. aureus intravenous catheter infections.
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