期刊
JOURNAL OF INFECTIOUS DISEASES
卷 217, 期 2, 页码 232-237出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jix579
关键词
Ebola; transmission chains; intrahousehold; risk factors; secondary attack rate
资金
- Save the Children internal funds
- Wellcome Trust's Enhancing Research Activity in Epidemic Situations (ERAES) [107779/Z/15/Z]
- Wellcome Trust [107779/Z/15/Z] Funding Source: Wellcome Trust
Transmission between family members accounts for most Ebola virus transmission, but little is known about determinants of intrahousehold spread. From detailed exposure histories, intrahousehold transmission chains were created for 94 households of Ebola survivors in Sierra Leone: 109 (co-) primary cases gave rise to 317 subsequent cases (0-100% of those exposed). Larger households were more likely to have subsequent cases, and the proportion of household members affected depended on individual and household-level factors. More transmissions occurred from older than from younger cases, and from those with more severe disease. The estimated household secondary attack rate was 18%.
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