期刊
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
卷 45, 期 -, 页码 61-67出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2016.09.003
关键词
Tissue engineering; Hydrogel scaffold; BFP1; 3D printing; Bone regeneration
资金
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI) - Ministry of Health & Welfare, Republic of Korea [HI14C2241]
In this research, novel 3D printed alginate-peptide hybrid scaffolds were explored for enhanced bone regeneration. Bone formation peptide-1 (BFP1) was loaded into the scaffolds to promote bone regeneration. The alginate-BFP1 conjugates were synthesized via a facile EDC/NHS coupling reaction and then cross-linked in the presence of calcium ions to form hydrogel networks. The dose-dependent cytotoxicity of CaCl2 was evaluated to optimize the amount of Ca2+ for fabrication of scaffolds. In vitro and in vivo studies indicated that the alginate-based scaffolds provided a stable environment for the growth of human adipose-derived stem cells (hADSCs) and led to a synergistically enhanced bone regeneration. (C) 2016 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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