4.6 Article

Nlrp12 Mediates Adverse Neutrophil Recruitment during Influenza Virus Infection

期刊

JOURNAL OF IMMUNOLOGY
卷 200, 期 3, 页码 1188-1197

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AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1700999

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  1. National Institutes of Health [R01 AI118719, R01 AI104706, T32 AI007485]
  2. American Lung Association/American Academy of Allergy, Asthma & Immunology Foundation

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Exaggerated inflammatory responses during influenza Avirus (IAV) infection are typically associated with severe disease. Neutrophils are among the immune cells that can drive this excessive and detrimental inflammation. In moderation, however, neutrophils are necessary for optimal viral control. In this study, we explore the role of the nucleotide-binding domain leucine-rich repeat containing receptor family member Nlrp12 in modulating neutrophilic responses during lethal IAV infection. Nlrp12(-/-) mice are protected from lethality during IAV infection and show decreased vascular permeability, fewer pulmonary neutrophils, and a reduction in levels of neutrophil chemoattractant CXCL1 in their lungs compared with wild-type mice. Nlrp12(-/-) neutrophils and dendritic cells within the IAV-infected lungs produce less CXCL1 than their wild-type counterparts. Decreased CXCL1 production by Nlrp12(-/-) dendritic cells was not due to a difference in CXCL1 protein stability, but instead to a decrease in Cxcl1 mRNA stability. Together, these data demonstrate a previously unappreciated role for Nlrp12 in exacerbating the pathogenesis of IAV infection through the regulation of CXCL1-mediated neutrophilic responses.

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