期刊
JOURNAL OF IMMUNOLOGY
卷 199, 期 2, 页码 397-402出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1601999
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资金
- National Institutes of Health [AI-056234, AI-119833, AI-126050, T32-AI-007077]
- Russian Science Fund Project [15-15-00100]
- Russian Science Foundation [15-15-00100] Funding Source: Russian Science Foundation
Stimulator of interferon genes (STING) was initially described as a sensor of intracellular bacterial and viral DNA and a promising adjuvant target in innate immune cells; more recently STING has also been shown to detect endogenous DNA and play a role in tumor immunity and autoimmune disease development. Thus far STING has been studied in macrophages and dendritic cells. In this study, to our knowledge we provide the first evidence of STING activation in T cells, in which STING agonists not only provoke type I IFN production and IFN-stimulated gene expression, mirroring the response of innate cells, but are also capable of activating cell stress and death pathways. Our results suggest a re-evaluation of STING agonist-based therapies may be necessary to identify the possible effects on the T cell compartment. Conversely, the effects of STING on T cells could potentially be harnessed for therapeutic applications.
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