期刊
JOURNAL OF IMMUNOLOGY
卷 199, 期 10, 页码 3571-3582出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1700091
关键词
-
类别
资金
- National Natural Science Foundation of China [31300744, 81373132]
- Specialized Research Fund for the Doctoral Program of Higher Education of China [20130141120011]
Long noncoding RNAs, a newly identified class of noncoding RNAs, are important regulators of gene expression in innate immunity. We report in this study that the transcription of FIRRE, a conserved long noncoding RNA between humans and mice, is controlled by NF-kappa B signaling in macrophages and intestinal epithelial cells. Functionally, FIRRE appears to positively regulate the expression of several inflammatory genes in macrophages or intestinal epithelial cells in response to LPS stimulation via posttranscriptional mechanisms. Specifically, FIRRE physically interacts with heterogeneous nuclear ribonucleoproteins U, regulating the stability of mRNAs of selected inflammatory genes through targeting the AU-rich elements of their mRNAs in cells following LPS stimulation. Therefore, our data indicate a new regulatory role for NF-kappa B-responsive FIRRE in the posttranscriptional regulation of inflammatory genes in the innate immune system.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据