期刊
CHINESE JOURNAL OF PHYSIOLOGY
卷 62, 期 6, 页码 231-240出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/CJP.CJP_67_19
关键词
CDK5; cytoskeletal remodeling; DNA damage; lung cancer; PD-L1; tumor suppressor
类别
资金
- Ministry of Science and Technology, Taiwan [106-2320-B-005-002-MY3/108-2 911-I-005-509]
- NCHU ENABLE Center [108-16]
- Tungs' Taichung MetroHarbor Hospital [TTMHH-NCHULS107004]
- Taichung Veterans General Hospital/National Chung Hsing University Joint Research Program [TCVGH-NCHU-1097615]
Lung harbors the growth of primary and secondary tumors. Even though numerous factors regulate the complex signal transduction and cytoskeletal remodeling toward the progression of lung cancer, cyclin-dependent kinase 5 (Cdk5), a previously known kinase in the central nervous system, has raised much attention in the recent years. Patients with aberrant Cdk5 expression also lead to poor survival. Cdk5 has already been employed in various cellular processes which shape the fate of cancer. In lung cancer, Cdk5 mainly regulates tumor suppressor genes, carcinogenesis, cytoskeletal remodeling, and immune checkpoints. Inhibiting Cdk5 by using drugs, siRNA or CRISP-Cas9 system has rendered crucial therapeutic advantage in the combat against lung cancer. Thus, the relation of Cdk5 to lung cancer needs to be addressed in detail. In this review, we will discuss various cellular events modulated by Cdk5 and we will go further into their underlying mechanism in lung cancer.
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