期刊
JOURNAL OF IMMUNOLOGY
卷 199, 期 1, 页码 62-71出版社
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.1600848
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- Center for Technologies against Cancer, Tokyo University of Science
Epidermal gamma delta T cells that reside in the front line of the skin play a pivotal role in stress immune surveillance. However, it is not clear whether these cells are involved in further induction of immune responses after they are activated in dysregulated epidermis. In this study, we found that activated gamma delta T cells expressed occludin and migrated into draining lymph nodes in an occludindependent manner. Epidermal gamma delta T cells in occludin-deficient mice exhibited impairments in morphology changes and motility, although they expressed activation markers at levels comparable to those in wild- type cells. Occludin deficiency weakened the induction of allergen- induced contact hypersensitivity, primarily as the result of the impaired migration of epidermal gamma delta T cells. Thus, occludin expression by epidermal gamma delta T cells upon activation in response to epidermal stress allows them to move, which could be important for augmentation of immune responses via collaboration with other cells.
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