期刊
JOURNAL OF HYPERTENSION
卷 35, 期 10, 页码 2095-2101出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/HJH.0000000000001411
关键词
antihypertensive medication; blood pressure; dementia; hypertension
资金
- Dutch Ministry of Health, Welfare and Sports [50-50110-98-020]
- Innovatiefonds Zorgverzekeraars [05-234]
- ZonMw (The Netherlands Organisation for Health Research and Development) [62000015]
- EU
- Academy of Finland) [291803]
- France, L'Agence Nationale de la Recherche (The French National Research Agency) [ANR-14-JPPS-0001-02]
- Germany, Bundesministerium fur Bildung und Forschung (BMBF) (The Federal Ministry of Education and Research) [FKZ01ED1509]
- Sweden, Vetenskapsradet (VR) (Swedish Research Council) [529-2014-7503]
- Netherlands, ZonMw (The Netherlands Organisation for Health Research and Development) [733051041]
- European Union [305374]
- Agence Nationale de la Recherche (ANR) [ANR-14-JPPS-0001] Funding Source: Agence Nationale de la Recherche (ANR)
Objective:Use of antihypertensive medication (AHM) is potentially associated with a reduced risk of dementia. Both calcium channel blockers (CCBs) and angiotensin receptor blockers (ARBs) are suggested to have a more pronounced protective effect. We aimed to study the association between different classes of AHM and dementia in older people.Methods:A subgroup of community-dwelling older people using AHM included in the Prevention of Dementia by Intensive Vascular Care' randomized controlled trial was studied. Incident dementia rates in participants with different AHM classes (mono and combination therapy) were compared with dementia rates in participants with any other AHM.Results:At baseline, 1951 participants (55.3%) used AHM [mean age, 74.4 year (SD 2.5); mean SBP, 156.4mmHg (SD 21.5)]. In total, 986 participants (50.5%) used -blockers, 798 diuretics (40.9%), 623 angiotensin- converting enzyme inhibitors (31.9%), 522 CCBs (26.8%), and 402 ARBs (20.6%). After 6.7 years (interquartile range 6.0-7.3) of follow-up, 136 participants (7.0%) developed dementia. Both use of CCBs [hazard ratio 0.56, 95% confidence interval (95% CI) 0.36-0.87] and ARBs (hazard ratio 0.60, 95% CI 0.37-0.98) were independently associated with a decreased risk of dementia. The association of CCBs with dementia was most apparent in participants without a history of cardiovascular disease (hazard ratio 0.38, 95% CI 0.18-0.81) and with uncontrolled hypertension (hazard ratio 0.26, 95% CI 0.11-0.61). SBP was not significantly lower in participants using CCBs or ARBs.Conclusion:Both use of CCBs and ARBs are independently associated with a decreased risk of dementia in older people.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据