期刊
DEVELOPMENTAL CELL
卷 35, 期 3, 页码 269-280出版社
CELL PRESS
DOI: 10.1016/j.devcel.2015.10.019
关键词
-
资金
- NIH [GM047892]
- Research to Prevent Blindness
The basic Helix-Loop-Helix (bHLH) proteins represent a well-known class of transcriptional regulators. Many bHLH proteins act as heterodimers with members of a class of ubiquitous partners, the E proteins. A widely expressed class of inhibitory heterodimer partners-the Inhibitor of DNA-binding (ID) proteins-also exists. Genetic and molecular analyses in humans and in knockout mice implicate E proteins and ID proteins in a wide variety of diseases, belying the notion that they are non-specific partner proteins. Here, we explore relationships of E proteins and ID proteins to a variety of disease processes and highlight gaps in knowledge of disease mechanisms.
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