期刊
DEVELOPMENTAL CELL
卷 35, 期 1, 页码 12-20出版社
CELL PRESS
DOI: 10.1016/j.devcel.2015.09.012
关键词
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资金
- National Health and Medical Research Council of Australia [1044041, 1058565]
- NHMRC Program in Membrane Interface Biology [1037320]
- NHMRC [1067405]
- Australian Research Council
- Kids Cancer Project of the Oncology Research Foundation
- National Health and Medical Research Council of Australia [1067405, 1058565] Funding Source: NHMRC
This Perspective considers how classical cadherin cell-cell adhesion receptors are organized at the nanoscale to generate lateral clusters. Recent advances in optical microscopy reveal that clustering constitutes a general feature of cadherin organization, but one that takes diverse forms. Here we consider the molecular mechanisms responsible for cadherin clustering and their functional implications. We frame our discussion in light of what is known about how nanoscale organization is conferred upon the plasma membrane, through protein-protein interactions, regulation of the cortical actin cytoskeleton, and the lipid environment of the membrane.
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