期刊
DEVELOPMENTAL CELL
卷 32, 期 4, 页码 423-434出版社
CELL PRESS
DOI: 10.1016/j.devcel.2015.01.035
关键词
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资金
- Boston Children's Hospital Developmental Neurology Training Grant [T32NS007473]
- Harvard Stem Cell Institute Training Grant [T32HL087735]
- Harvard Medical School Goldenson Fellowship
- NIGMS [T32GM007753]
- NINDS
- NIMH
The development and function of our brain are governed by a genetic blueprint, which reflects dynamic changes over the history of evolution. Recent progress in genetics and genomics, facilitated by next-generation sequencing and single-cell sorting, has identified numerous genomic loci that are associated with a neuroanatomical or neurobehavioral phenotype. Here, we review some of the genetic changes in both protein-coding and noncoding regions that affect brain development and evolution, as well as recent progress in brain transcriptomics. Understanding these genetic changes may provide novel insights into neurological and neuropsychiatric disorders, such as autism and schizophrenia.
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