期刊
DEVELOPMENTAL CELL
卷 34, 期 1, 页码 5-17出版社
CELL PRESS
DOI: 10.1016/j.devcel.2015.06.004
关键词
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资金
- Deutsche Forschungsgemeinschaft [SFB873, SFB-TR23]
- EU
- Helmholtz Alliance Preclinical Comprehensive Cancer Center
- Leducq Foundation Transatlantic Network of Excellence
- endowed chair from the Aventis Foundation
The field of angiogenesis research has primarily focused on the mechanisms of sprouting angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo extensive vascular remodeling to form a functional and mature vasculature. This trimming'' includes distinct processes of vascular pruning, the regression of selected vascular branches. In some situations complete vascular networks may undergo physiological regression. Vessel regression is an understudied yet emerging field of research. This review summarizes the state-of-the-art of vessel pruning and regression with a focus on the cellular processes and the molecular regulators of vessel maintenance and regression.
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