期刊
DEVELOPMENTAL CELL
卷 32, 期 4, 页码 478-490出版社
CELL PRESS
DOI: 10.1016/j.devcel.2015.01.019
关键词
-
资金
- Japanese Ministry of Education, Science, Sports, Culture, and Technology
Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system development In the vertebrate peripheral nervous system, PCD is the basis of the neurotrophic theory, whereby cell death results from a surplus of neurons relative to target and competition for neurotrophic factors. In addition to stochastic cell death, PCD can be intrinsically determined by cell lineage or position and timing in both invertebrate and vertebrate central nervous systems. The underlying PCD molecular mechanisms include intrinsic transcription factor cascades and regulators of competence/susceptibility to cell death. Here, we provide a framework for understanding neural PCD from its regulation to its functions.
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