期刊
DIFFUSE OPTICAL SPECTROSCOPY AND IMAGING VII
卷 11074, 期 -, 页码 -出版社
SPIE-INT SOC OPTICAL ENGINEERING
DOI: 10.1117/12.2527065
关键词
Time-domain techniques; speckle imaging; blood flow
资金
- Fundacion Cellex
- Instituto de Salud Carlos III (ISCIII) [DTS16/00087]
- Ministerio de Economia y Competitividad (MINECO) [DPI2015-64358-C2-1-R]
- la Caixa Foundation
- Severo Ochoa Programme for Centres of Excellence in RD [SEV-2015-0522]
- Agencia de Gestio d'Ajuts Universitaris i de Recerca (AGAUR) [2017 SGR 1380]
- Laserlab Europe IV
- Horizon 2020 Framework Programme (H2020) [688303H2020-ICT-2015]
- Institucio CERCA
Time-domain diffuse correlation spectroscopy (TD-DCS) is an emerging optical technique with the potential to resolve the blood flow (BF) in depth. The first in vivo measurements have been shown recently on humans, however improvements in terms of signal-to-noise ratio (SNR) and depth sensitivity would be beneficial for biological applications. In this contribution, we explore the possibility of in vivo TD-DCS measurements above 1000 nm, and discuss its possible advantages compared to standard wavelengths (i.e. 700-800 nm). In our experimental setup, we exploited a tunable pulsed laser source extended more to the infrared and an InGaAs photomultiplier. Here, we report the results of a cuff occlusion on the forearm of a healthy adult subject at a wavelength of 1000 nm. Compared to the same experiment at standard wavelength (785 nm), the electric-field auto-correlation functions show a slower decay rate during all the experiment (both during and after the occlusion) as expected, suggesting a higher SNR. Even longer wavelengths, for diminishing water absorption, can be obtained through optimization of the laser source and the use of more efficient detectors.
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