期刊
DEVELOPMENTAL BIOLOGY
卷 398, 期 2, 页码 206-217出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2014.11.021
关键词
P body; Oogenesis; Insulin; Dynein; Kinesin; Microtubule
资金
- National Institutes of Health [GM043301]
- National Institutes of Health Developmental Biology Training Grant [T32 HD007180]
- Japan Society for the Promotion of Science
Egg chambers from starved Drosophila females contain large aggregates of processing (P) bodies and cortically enriched microtubules. As this response to starvation is rapidly reversed upon re-feeding females or culturing egg chambers with exogenous bovine insulin, we examined the role of endogenous insulin signaling in mediating the starvation response. We found that systemic Drosophila insulin-like peptides (dILPs) activate the insulin pathway in follicle cells, which then regulate both microtubule and P body organization in the underlying germline cells. This organization is modulated by the motor proteins Dynein and Kinesin. Dynein activity is required for microtubule and P body organization during starvation, while Kinesin activity is required during nutrient-rich conditions. Blocking the ability of egg chambers to form P body aggregates in response to starvation correlated with reduced progeny survival. These data suggest a potential mechanism to maximize fecundity even during periods of poor nutrient availability, by mounting a protective response in immature egg chambers. (C) 2014 Elsevier Inc. All rights reserved.
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