期刊
DEVELOPMENTAL BIOLOGY
卷 401, 期 1, 页码 152-164出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2014.12.005
关键词
Morphogenesis; Elastic modulus; Adhesion energy; Surface tension; Stiffness; Binding energy
资金
- National Science Foundation [IOS-0845775, CMMI-1100515]
- National Institutes of Health [HD044750]
- NIH Biomechanics in Regenerative Medicine Training Grant (BiRM) [T32 EB003392]
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0845775] Funding Source: National Science Foundation
- Div Of Civil, Mechanical, & Manufact Inn
- Directorate For Engineering [1100515] Funding Source: National Science Foundation
During development cells interact mechanically with their microenvironment through cell-cell and cell-matrix adhesions. Many proteins involved in these adhesions serve both mechanical and signaling roles. In this review we will focus on the mechanical roles of these proteins and their complexes in transmitting force or stress from cell to cell or from cell to the extracellular matrix. As forces operate against tissues they establish tissue architecture, extracellular matrix assembly, and pattern cell shapes. As tissues become more established, adhesions play a major role integrating cells with the mechanics of their local environment. Adhesions may serve as both a molecular-specific glue, holding defined populations of cells together, and as a lubricant, allowing tissues to slide past one another. We review the biophysical principles and experimental tools used to study adhesion so that we may aid efforts to understand how adhesions guide these movements and integrate their signaling functions with mechanical function. As we conclude we review efforts to develop predictive models of adhesion that can be used to interpret experiments and guide future efforts to control and direct the process of tissue self-assembly during development. (C) 2014 Elsevier Inc. All rights reserved.
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