期刊
DEVELOPMENTAL BIOLOGY
卷 401, 期 1, 页码 143-151出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2014.12.023
关键词
Connexin; Development; Cancer; Cell migration; Polarity
资金
- MRC [MR/J000655/1]
- Wellcome Trust
- Latsis Public Benefit Foundation
- Biotechnology and Biological Sciences Research Council [BB/M008517/1] Funding Source: researchfish
- Medical Research Council [MR/M010465/1, MR/J000655/1] Funding Source: researchfish
- BBSRC [BB/M008517/1] Funding Source: UKRI
- MRC [MR/M010465/1, MR/J000655/1] Funding Source: UKRI
Connexins, the gap junction proteins, through their multitude of actions are implicated in a variety of cell processes during animal development and cancer. They allow direct or paracrine/autocrine cell communication through their channel and hemi-channel functions. They enable adhesion and interact with a plethora of signalling molecules. Here, we review the common themes in developmental and pathological processes and we focus in their involvement in cell migration in four different systems: neurons, astrocytes, neural crest and cancer. (C) 2014 Elsevier Inc. All rights reserved.
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