期刊
DEVELOPMENTAL BIOLOGY
卷 402, 期 2, 页码 208-215出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ydbio.2015.03.021
关键词
Retina; Spitz; EGFR; Apoptosis; Drosophila
资金
- Fondation ARC
- Fondation de France
- ANR [ANR-12-BSV1-0019-01, 13-ISV4-0003-01]
- Ministere de l'Enseignement Superieur et de la Recherche
- Fondation de France Parkinson
Apoptosis is required during development to eliminate superfluous cells and sculpt tissues; spatial and timed control of apoptosis ensures that the necessary number of cells is eliminated at a precise time in a given tissue. The elimination of supernumerary pigment or inter-ommatidial cells (IOCs) depends on cell-cell communication and is necessary for the formation of the honeycomb-like structure of the Drosophila eye. However, the mechanisms occurring during pupal development and controlling apoptosis of superfluous IOC in space and time remain unclear. Here, we found that split-ends (spen) is required for IOC survival at the time of removal of superfluous IOCs. Loss of spen function leads to abnormal removal of IOCs by apoptosis. We show that spen is required non-autonomously in cone cells for the survival of IOCs by positively regulating the Spitz/EGFR pathway. We propose that Spen is an important survival factor that ensures spatial control of the apoptotic wave that is necessary for the correct patterning and formation of the Drosophila eye. (C) 2015 Elsevier Inc. All rights reserved.
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