期刊
MATTER
卷 1, 期 2, 页码 496-512出版社
CELL PRESS
DOI: 10.1016/j.matt.2019.03.007
关键词
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资金
- National Natural Science Foundation of China [21874103, 81602610]
- National Basic Research Program of China (973 Program) [2015CB932601]
- Jiangsu Provincial Natural Science Foundation of China [BK20161248, BK20160381]
- Wu-han Youth Science and Technology Plan [2016070204010131]
- Fundamental Research Funds for the Central Universities [2042018kf0210]
An elaborately designed multifunctional nanoplatform with intelligent and inherent tumor-specific theranostic capacity is urgently desired for highly efficient cancer treatments. Herein, we report a class of compact MnO2-laden black phosphorus ( BPN/MnO2) nanostructure for delivering drugs with smart tumor-specific diagnosis and exquisite self-driven therapeutic features. The auxiliary MnO2 nanosheets promote the photodynamic therapy (PDT) of black phosphorus nanosheets (BPNs) by 3.8-fold through their inherent remarkable hypoxia amelioration. Moreover, BPN/MnO2 shows an obvious 37% photothermal therapy (PTT) enhancement relative to BPNs. Significantly, the multiple-tumor-microenvironment-responsive features of MnO2 contribute to the maximized drug administration on the tumor (>= 4-fold drug release of the single acid stimuli), thus reducing the potential side effect of chemotherapy on normal tissues. Besides the spatiotemporally programmable administration of drugs, BPN/MnO2 also provides intelligent MRI and thermal imaging guidance for synergistically enhancing PDT, PTT, and chemotherapy, thus offering an intelligent versatile toolbox for multifunctional nanotheranostic applications.
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