期刊
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
卷 24, 期 11, 页码 616-626出版社
WILEY
DOI: 10.1002/jhbp.502
关键词
Anatomic resection; Hepatocellular carcinoma; Non-anatomic resection; Overall survival
资金
- Grants-in-Aid for Scientific Research [15K10166] Funding Source: KAKEN
BackgroundThe aim of the present study was to compare the prognostic impact of anatomic resection (AR) versus non-anatomic resection (NAR) on patient survival after resection of a single hepatocellular carcinoma (HCC). MethodsTo control for confounding variable distributions, a 1-to-1 propensity score match was applied to compare the outcomes of AR and NAR. Among 710 patients with a primary, solitary HCC of <5.0cm in diameter that was resectable by either AR or NAR from 2003 to 2007 in Japan and Korea, 355 patients underwent NAR and 355 underwent AR of at least one section with complete removal of the portal territory containing the tumor. ResultsOverall survival (OS) was better in the AR than NAR group (hazard ratio 1.67, 95% confidence interval 1.28-2.19, P<0.001) while disease-free survival showed no significant difference. Significantly fewer patients in the AR than NAR group developed intrahepatic HCC recurrence and multiple intrahepatic recurrences. Patients with poorly differentiated HCC who underwent AR had improved disease-free survival and OS. ConclusionsAnatomic resection decreases the risk of tumor recurrence and improves OS in patients with a primary, solitary HCC of <5.0cm in diameter.
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