期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 48, 期 1, 页码 254-265出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2014.03.014
关键词
Allorecognition; Botryllus schlosseri; Invertebrate; fuhc; Evolution; Innate immunity
资金
- NIA NIH HHS [R01 AG037966] Funding Source: Medline
- NIGMS NIH HHS [R01 GM123267] Funding Source: Medline
- NATIONAL INSTITUTE ON AGING [R01AG037966] Funding Source: NIH RePORTER
Allorecognition has been well-studied in the context of vertebrate adaptive immunity and recognition of the Major Histocompatibility Complex (MHC), which is the central event of vertebrate immune responses. Although allorecognition systems have been identified throughout the metazoa, recent results have shown that there is no apparent conservation or orthologous relationship between the mechanisms underlying this phenomenon in different organisms. Thus the origin of the vertebrate adaptive immune system as well as these other complex recognition systems is a complete mystery. This review will focus on allorecognition in Botryllus schlosseri, a basal chordate which undergoes a natural transplantation reaction following contact between two individuals, and, analogous to vertebrates, is controlled by a single locus. We will summarize each of the known candidate genes within this locus and their potential roles in allorecognition, and speculate on how these findings may in fact be revealing potential functional relationships between disparate allorecognition systems. (C) 2014 Elsevier Ltd. All rights reserved.
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