期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 51, 期 2, 页码 298-304出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2015.01.006
关键词
Zebrafish; Danio redo; Mda5; Rhabdovirus; Type I IFN; Antiviral
资金
- National Institutes of Health [RO1 GM087308, R15A1065509]
- Maine Agricultural and Forest Experiment Station [3402]
- Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103423]
Melanoma Differentiation-Associated protein 5 (MDA5) is a member of the retinoic acid-inducible gene I (RIG-I)-like receptor (RLR) family, which is a cytosolic pattern recognition receptor that detects viral nucleic acids. Here we show an Mda5-dependent response to rhabdovirus infection in vivo using a dominant-negative mda5 transgenic zebrafish. Dominant-negative mda5 zebrafish embryos displayed an impaired antiviral immune response compared-to wild-type counterparts that can be rescued by recombinant full-length Mda5. To our knowledge, we have generated the first dominant-negative mda5 transgenic zebrafish and demonstrated a critical role for Mda5 in the antiviral response to rhabdovirus. (C) 2015 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据