期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 48, 期 1, 页码 22-32出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2014.08.011
关键词
Lipoteichoic acid; Toll-like receptor 2; Nitric oxide; In ovo; Infectious laryngotracheitis virus; Macrophage
资金
- Canadian Poultry Research Council [AMN048]
- Alberta Livestock and Meat Agency [2011R037R]
- Natural Sciences and Engineering Research Council (NSERC) of Canada through a NSERC-RTI grant [421963-2012]
Lipoteichoic acid (LTA) is one of the pathogen associated molecular patterns (PAMPs) that activates toll-like receptor (TLR)2-cluster of differentiation (CD)14 signalling pathway. This recognition elicits antiviral responses that have been recorded against viruses of mammals although such responses have not been characterized adequately against avian viruses. In this investigation, we characterized the LTA induced antiviral responses against infectious laryntotracheitis virus (ILTV) infection in vitro and in vivo. We found that LTA is capable of up regulating mRNA expression of innate proteins in macrophages such as MyD88, iNOS and IL-1 beta and reduces the ILTV plaques in vitro. Similarly, we found that LTA treatment of embryonic day 18 (ED18) eggs can lead to the antiviral response against pre-hatch ILTV infection in vivo and is associated with expansion of macrophage populations and expression of IL-1 beta and MyD88 in the lung. The data highlight that LTA can be a potential innate immune stimulant that can be used against ILTV infection in chickens. (C) 2014 Elsevier Ltd. All rights reserved.
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