期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 339, 期 -, 页码 174-181出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jhazmat.2017.06.033
关键词
Ciprofloxacin chlorination products; Biotransformation; Bacterial community; Antibiotic resistance genes; Genotoxicity
资金
- National Natural Science Foundation of China [51290281]
- project of Chinese Academy of Sciences [QYZDY-SSW-DQC004]
- Federal Department of Chinese Water Control and Treatment [2017ZX07108, 2017ZX07501002]
The interaction of ciprofloxacin chlorination products (CIP-CPs) with bacteria in drinking water distribution systems (DWDSs) was investigated. The piperazine ring of CIP was destroyed by chlorination. Among of CIP-CPs, by the bacterial role, 7.63% of the derivative with two carboxylic groups went through decarboxylation to form desethylene ciprofloxacin, and then loss of C2H5N group generated aniline compound. Furthermore, 12.3% of the aniline compound, 7.60% of chlorinated aniline compound and 1.35% of defluorinated product were bio-mineralized. Therefore, the chlorine and bacteria played synergistic effects on transformation of CIP-CPs in DWDSs, contributing to the obvious decrease of genotoxicity in effluents. Correspondingly, the TEQ(4-NQO) decreased from 667 mu g/L to 9.41 mu g/L. However, compared with DWDSs without CIP-CPs, the relative abundance of mexA and qnrS increased 1-fold in effluents and the relative abundance of qnrA and qnrB increased 3-fold in biofllms in DWDSs with CIP-CPs. mexA and qnrS positively correlated with Hyphomicrobium, Sphingomonas and Novosphingobium (p < 0.05), while qnrA and qnrB positively correlated with Shewanella and Helicobacter (p < 0.05), indicating the increase of antibiotic resistance genes (ARGs) came from the growth of these bacterial genera by transformation of CIP-CPs in DWDSs. These results suggested that biotransformation of antibiotics might increase ARGs risk in DWDSs. (C) 2017 Published by Elsevier B.V.
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