期刊
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
卷 52, 期 2, 页码 123-131出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.dci.2015.05.006
关键词
LFP-20; Lipopolysaccharide; Inflammation; MyD88; NF-kappa 8; MAPK
资金
- National Natural Science Foundation of China [31172435]
LFP-20 is one of the 20 amino acid anti-microbial peptides identified in the N terminus of porcine lactoferrin. Apart from its extensively studied direct anti-bacterial activity, its potential as an activator of immunerelated cellular functions is unknown. Therefore, this study investigated its anti-inflammatory effects in lipopolysaccharide (LPS)-stimulated pig alveolar macrophages in vitro and systemic inflammation in an in vivo mouse model. We found that the inhibitory effects of LFP-20 on production of pro-inflammatory cytokines were independent of its LPS-binding activity. However, they were associated with NP-kappa B and MAPK-dependent signaling. Furthermore, LFP-20 might directly influence MyD88 levels to block its interaction with NF-kappa B and MAPK-dependent signaling molecules that might alter LPS-mediated inflammatory responses in activated macrophages. Taken together, our data indicated that LFP-20 prevents the LPS-induced inflammatory response by inhibiting MyD88/NF-kappa B and MyD88/MAPK signaling pathways, and sheds light on the potential use of LFP-20 in the therapy of LPS-mediated sepsis. (C) 2015 Elsevier Ltd. All rights reserved.
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