期刊
JOURNAL OF HAZARDOUS MATERIALS
卷 327, 期 -, 页码 180-186出版社
ELSEVIER
DOI: 10.1016/j.jhazmat.2016.12.040
关键词
Genotoxicity; Zinc oxide nanoparticles; Drosophila melanogaster; Risk assessment; Nanotoxicology
资金
- DRDO,Govt of India [DIP-259]
- Department of Science and Technology, New Delhi
Zinc oxide nanoparticles (ZnO NPs) are commonly used nanomaterials (NMs) with versatile applications from high-end technologies to household products. This pervasive utilisation has brought human in the close interface with nanoparticles (NPs), hence questioning their safety prior to usage is a must. In this study, we have assessed the effects of chronic exposure to ZnO NPs (<50 nm) on the model organism Drosophila melanogaster. Potential toxic effects were studied by evaluating longevity, climbing ability, oxidative stress and DNA fragmentation. Ensuing exposure, the FO (parent), F1, F2, F3 and F4 generation flies were screened for the aberrant phenotype. Flies exposed to ZnO NPs showed distinctive phenotypic changes, like deformed segmented thorax and single or deformed wing, which were transmitted to the offspring's in subsequent generations. The unique abnormal phenotype is evident of chronic toxicity induced by ZnO NPs, although appalling, it strongly emphasize the importance to understand NPs toxicity for safer use. (C) 2016 Elsevier B.V. All rights reserved.
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