4.1 Article

Periostin, a neurite outgrowth-promoting factor, is expressed at high levels in the primate cerebral cortex

期刊

DEVELOPMENT GROWTH & DIFFERENTIATION
卷 57, 期 3, 页码 200-208

出版社

WILEY-BLACKWELL
DOI: 10.1111/dgd.12194

关键词

electroporation; macaque; marmoset; mouse; primary culture

资金

  1. NBRP Japanese Monkeys through the National Bio-Resource Project of the MEXT, Japan
  2. JSPS KAKENHI [25750403]
  3. Takeda Science Foundation
  4. JSPS through the Funding Program for World-Leading Innovative R&D on Science and Technology (FIRST Program), - initiated by the Council for Science and Technology Policy (CSTP)
  5. Brain Mapping by Integrated Neurotechnologies for Disease Studies (Brain/MINDS) by the MEXT of Japan
  6. Grants-in-Aid for Scientific Research [25750403] Funding Source: KAKEN

向作者/读者索取更多资源

Periostin (POSTN or osteoblast specific factor) is an extracellular matrix protein originally identified as a protein highly expressed in osteoblasts. Recently, periostin has been reported to function in axon regeneration and neuroprotection. In the present study, we focused on periostin function in cortical evolution. We performed a comparative gene expression analysis of periostin between rodents (mice) and primates (marmosets and macaques). Periostin was expressed at higher levels in the primate cerebral cortex compared to the mouse cerebral cortex. Furthermore, we performed overexpression experiments of periostin invivo and invitro. Periostin exhibited neurite outgrowth activity in cortical neurons. These results suggested the possibility that prolonged and increased periostin expression in the primate cerebral cortex enhances the cortical plasticity of the mammalian cerebral cortex.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.1
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据