期刊
FOOD CHEMISTRY-X
卷 4, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.fochx.2019.100056
关键词
Selective androgen receptor modulators; SARMs; UHPLC-MS/MS; Muscle tissue; Residue screening; Food safety
资金
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie [642380]
- Marie Curie Actions (MSCA) [642380] Funding Source: Marie Curie Actions (MSCA)
Selective androgen receptor modulators (SARMs) are non-steroidal compounds widely reported as drugs of abuse in human and animal sports, with potential for misuse as growth promoters in animal-based food production. In this study, a first analytical methodology to simultaneous screen for a panel of emerging SARMs in bovine muscle was developed, validated (CC beta values from 0.5-5 ng g(-1)), and applied to detect 15 structurally diverse compounds from nine SARM families. Muscle samples (200 mg) were homogenised in extraction solvent (MeCN:H2O, 4:1, v/v) before clean-up (end-capped C18 dSPE), defatting (n-hexane pre-saturated with MeCN partitioning) and concentration prior to UHPLC-MS/MS analysis. In the absence of incurred bovine muscle, method applicability was demonstrated by the analysis of rodent muscle tissue. The developed screening assay serves as a rapid, simple and cost-effective tool for surveillance monitoring of SARM abuse in livestock production systems as a pre-emptive measure ensuring food safety.
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