期刊
DEVELOPMENT
卷 142, 期 4, 页码 665-671出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.115964
关键词
Somite; Dermomyotome; Filopodia; FiLiPs; Frizzled-7
资金
- Deutsche Forschungsgemeinschaft [SFB592, GRK1104]
- Imhoff-Stiftung
Long-range intercellular communication is essential for the regulation of embryonic development. Apart from simple diffusion, various modes of signal transfer have been described in the literature. Here, we describe a novel type of cellular extensions found in epithelial cells of the somites in chicken embryos. These filopodia-like protrusions span the subectodermal space overlying the dorsal surface of the somites and contact the ectoderm. We show that these protrusions are actin-and tubulin-positive and require Rac1 for their formation. The presence of glycophosphatidylinositol-anchored proteins and net retrograde trafficking of the transmembrane Wnt-receptor Frizzled-7 along the protrusions indicate their role in signal transport and distribution. Taken together, our data suggest a role of filopodia-like protrusions in mediating signaling events between distant epithelial cells during embryonic development.
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