The pluripotent state in mouse and human

In the mouse, naive pluripotent stem cells (PSCs) are thought to represent the cell culture equivalent of the late epiblast in the preimplantation embryo, with which they share a unique defining set of features. Recent studies have focused on the identification and propagation of a similar cell state in human. Although the capture of an exact human equivalent of the mouse naive PSC remains an elusive goal, comparative studies spurred on by this quest are lighting the path to a deeper understanding of pluripotent state regulation in early mammalian development.