期刊
DEVELOPMENT
卷 142, 期 21, 页码 3620-3629出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.120394
关键词
Taste buds; Gustatory system; Sonic hedgehog; Wnt/beta-catenin; Cell lineage; Molecular genetics; Taste dysfunction; Dysgeusia; Ageusia; Chemotherapy; Stem cells; Lingual organoids
资金
- NIH/NIDCD [DC012383, DC012675]
The sense of taste, or gustation, is mediated by taste buds, which are housed in specialized taste papillae found in a stereotyped pattern on the surface of the tongue. Each bud, regardless of its location, is a collection of similar to 100 cells that belong to at least five different functional classes, which transduce sweet, bitter, salt, sour and umami (the taste of glutamate) signals. Taste receptor cells harbor functional similarities to neurons but, like epithelial cells, are rapidly and continuously renewed throughout adult life. Here, I review recent advances in our understanding of how the pattern of taste buds is established in embryos and discuss the cellular and molecular mechanisms governing taste cell turnover. I also highlight how these findings aid our understanding of how and why many cancer therapies result in taste dysfunction.
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