期刊
DEVELOPMENT
卷 142, 期 4, 页码 644-653出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.113357
关键词
Intestinal stem cell; Secretory enteroendocrine cell; Pre-enteroendocrine cell; Prospero; Drosophila
资金
- Intramural Research Program of the National Cancer Institute, National Institutes of Health
Functional mature cells are continually replenished by stem cells to maintain tissue homoeostasis. In the adult Drosophila posteriormidgut, both terminally differentiated enterocyte (EC) and enteroendocrine (EE) cells are generated from an intestinal stem cell (ISC). However, it is not clear how the two differentiated cells are generated from the ISC. In this study, we found that only ECs are generated through the Su(H) GBE(+) immature progenitor enteroblasts (EBs), whereas EEs are generated from ISCs through a distinct progenitor pre-EE by a novel lineage-tracing system. EEs can be generated from ISCs in three ways: an ISC becoming an EE, an ISC becoming a new ISC and an EE through asymmetric division, or an ISC becoming two EEs through symmetric division. We further identified that the transcriptional factor Prospero ( Pros) regulates ISC commitment to EEs. Our data provide direct evidence that different differentiated cells are generated by different modes of stem cell lineage specification within the same tissues.
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