期刊
DEVELOPMENT
卷 142, 期 9, 页码 1555-1560出版社
COMPANY OF BIOLOGISTS LTD
DOI: 10.1242/dev.121590
关键词
Neural crest; Mouse; Zebrafish; Xenopus; Chicken; Gene knockout
资金
- Biotechnology and Biological Sciences Research Council [BB/M008517/1] Funding Source: researchfish
- Medical Research Council [MR/M010465/1, MR/J000655/1] Funding Source: researchfish
- BBSRC [BB/M008517/1] Funding Source: UKRI
- MRC [MR/J000655/1, MR/M010465/1] Funding Source: UKRI
- Medical Research Council [MR/J000655/1, MR/M010465/1] Funding Source: Medline
- NICHD NIH HHS [P01 HD037105, HD037105] Funding Source: Medline
- NIDCR NIH HHS [R01 DE016082, DE 016082, DE024157, R01 DE024157] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The neural crest is a uniquely vertebrate cell type and has been well studied in a number of model systems. Zebrafish, Xenopus and chick embryos largely show consistent requirements for specific genes in early steps of neural crest development. By contrast, knockouts of homologous genes in the mouse often do not exhibit comparable early neural crest phenotypes. In this Spotlight article, we discuss these species-specific differences, suggest possible explanations for the divergent phenotypes in mouse and urge the community to consider these issues and the need for further research in complementary systems.
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