期刊
DEVELOPMENT
卷 142, 期 4, 页码 620-632出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.106567
关键词
MITF; Melanoma; Neural crest; Stem cells
资金
- Medical Research Council
- Medical Research Scotland
- National Centre for the 3Rs (NC3Rs)
- MRC [MC_PC_U127585840, MC_U127585840, MC_PC_U127561112, MC_PC_U127527200] Funding Source: UKRI
- Medical Research Council [MC_PC_U127585840, MC_PC_U127561112, MC_PC_U127527200, MC_U127585840] Funding Source: researchfish
- National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) [NC/K001612/1] Funding Source: researchfish
Melanocyte development provides an excellent model for studying more complex developmental processes. Melanocytes have an apparently simple aetiology, differentiating from the neural crest and migrating through the developing embryo to specific locations within the skin and hair follicles, and to other sites in the body. The study of pigmentation mutations in the mouse provided the initial key to identifying the genes and proteins involved in melanocyte development. In addition, work on chicken has provided important embryological and molecular insights, whereas studies in zebrafish have allowed live imaging as well as genetic and transgenic approaches. This cross-species approach is powerful and, as we review here, has resulted in a detailed understanding of melanocyte development and differentiation, melanocyte stem cells and the role of the melanocyte lineage in diseases such as melanoma.
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