期刊
JOURNAL OF GENERAL VIROLOGY
卷 98, 期 9, 页码 2258-2266出版社
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.000899
关键词
Bunyaviridae; Orthobunyavirus; Mermet virus; Tataguine virus; California encephalitis virus serogroup; genome sequence
资金
- NIH [HHSN272201000040I/HHSN2700004/D4, R24AI120942]
The Bunyaviridae family is made up of a diverse range of viruses, some of which cause disease and are a cause for concern in human and veterinary health. Here, we report the genomic and antigenic characterization of five previously uncharacterized bunyaviruses. Based on their ultrastructure, antigenic relationships and phylogenomic relationships, the five viruses are classified as members of the Orthobunyavirus genus. Three are viruses in the California encephalitis virus serogroup and are related to Trivittatus virus; the two others are most similar to the Mermet virus in the Simbu serogroup, and to the Tataguine virus, which is not currently assigned to a serogroup. Each of these five viruses was pathogenic to newborn mice, indicating their potential to cause illness in humans and other animals.
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