期刊
JOURNAL OF GENERAL VIROLOGY
卷 98, 期 7, 页码 1823-1830出版社
MICROBIOLOGY SOC
DOI: 10.1099/jgv.0.000834
关键词
inherited chromosomally integrated human herpesvirus 6; telomere repeat sequence; microsatellite; founder effect
资金
- Ministry of Education, Culture, Sports, Science
- Grants-in-Aid for Scientific Research [16K08981, 15H04710] Funding Source: KAKEN
Integration of the complete human herpesvirus 6 (HHV-6) genome into the telomere of a chromosome has been reported in some individuals (inherited chromosomally integrated HHV-6; iciHHV-6). Since the proportion of iciHHV-6-positive individuals with integration in chromosome 22 is high in Japan, we hypothesized a founder effect. In this study, we sought to elucidate the reason for the high proportion of viral integrations into chromosome 22. We analyzed six cases of iciHHV-6A and two cases of iciHHV-6B, including one iciHHV-6A case with a matched sample from a father and one iciHHV-6B case with a matched sample from a mother. In iciHHV-6A, the same copy numbers of viral telomeric repeat sequences (TRS) and the same five microsatellite markers were detected in both the index case and paternal sample. Moreover, the same five microsatellite markers were demonstrated in four cases and the same copy numbers of viral TRS were demonstrated in two pairs of two cases. The present microsatellite analysis suggested that the viral genomes detected in some iciHHV-6A patients were derived from a common ancestral integration.
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