期刊
QUARTERLY REVIEWS OF BIOPHYSICS
卷 52, 期 -, 页码 -出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0033583519000027
关键词
Quasielastic neutron spectroscopy; protein diffusion; protein backbone; protein side chains; molecular relaxations; colloid physics
类别
资金
- Deutsche Forschungsgemeinschaft (DFG)
- Agence Nationale de la Recherche [ANR-16-CE92-0009]
- ILL
- Studienstiftung des Deutschen Volkes
- Agence Nationale de la Recherche (ANR) [ANR-16-CE92-0009] Funding Source: Agence Nationale de la Recherche (ANR)
The dynamics of proteins in solution includes a variety of processes, such as backbone and side-chain fluctuations, interdomain motions, as well as global rotational and translational (i.e. center of mass) diffusion. Since protein dynamics is related to protein function and essential transport processes, a detailed mechanistic understanding and monitoring of protein dynamics in solution is highly desirable. The hierarchical character of protein dynamics requires experimental tools addressing a broad range of time- and length scales. We discuss how different techniques contribute to a comprehensive picture of protein dynamics, and focus in particular on results from neutron spectroscopy. We outline the underlying principles and review available instrumentation as well as related analysis frameworks.
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