期刊
DEVELOPMENT
卷 142, 期 4, 页码 607-619出版社
COMPANY BIOLOGISTS LTD
DOI: 10.1242/dev.091769
关键词
Activin; Cell cycle; Differentiation; Nodal; Pluripotency; Stem cells
资金
- EUFP7 grant InnovaLIV
- FEBS long-term fellowship
- ERC starting grant Relieve IMDs
- Cambridge Hospitals National Institute for Health Research Biomedical Research Centre
- MRC [G0800784, G0701448, G1000847] Funding Source: UKRI
- Medical Research Council [G0701448, G1000847, G0800784] Funding Source: researchfish
Activin/Nodal growth factors control a broad range of biological processes, including early cell fate decisions, organogenesis and adult tissue homeostasis. Here, we provide an overview of the mechanisms by which the Activin/Nodal signalling pathway governs stem cell function in these different stages of development. We describe recent findings that associate Activin/Nodal signalling to pathological conditions, focusing on cancer stem cells in tumorigenesis and its potential as a target for therapies. Moreover, we will discuss future directions and questions that currently remain unanswered on the role of Activin/Nodal signalling in stem cell self-renewal, differentiation and proliferation.
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