期刊
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
卷 32, 期 3, 页码 677-686出版社
WILEY
DOI: 10.1111/jgh.13537
关键词
Th22; Th17; IL-22; CHB; ACLF
资金
- National Natural Science Foundation of China [81171569, 81300316]
- National Key Programs on Infectious Diseases of China [2012ZX10002003-003, 2012ZX10002007-002, 2012ZX10002004-003]
- National Clinical Key Specialty Construction Project of China
- Three-year Action Plan of Public Health in Shanghai [15GW2K0102]
Background and Aim: Hepatitis B virus-related acute-on-chronic liver failure (HBVACLF) is an acute deterioration of liver function on chronic liver disease with immune disorder. Th22 cells and IL-22 were correlated with inflammatory and autoimmune diseases. However, Th22 cells and IL-22 in the pathogenesis of HBV-ACLF remains to be elucidated. It was investigated the correlation between Th22 and prognosis in HBVACLF. Methods: Seventy-one HBV-ACLF and 65 chronic hepatitis B patients were recruited. The peripheral frequencies of Th22, Th17 and Th1, or IL-22 and IL-17 were determined, using flow cytometry or ELISA, respectively. It was further analyzed the correlation between Th22 mediated circulating IL-22 and survival rate of HBV-ACLF patients. Results: It was upregulated that the peripheral frequencies of Th22/Th17 cells as well as plasma IL-22 and IL-17 in HBV-ACLF patients, but the frequency of Th1 cells was decreased, compared with health controls. Elevated Th22 cells and IL-22 were correlated with HBV-ACLF disease severity. Elevated plasma IL-22 level (>29.5 pg/ml) was correlated with poor survival rate of HBV-ACLF patients at baseline, using Kaplan-Meier analysis. Conclusions: Persistently elevated circulating Th22 reversely correlates with prognosis in HBV-ACLF. Th22 cells/IL-22 might be served as biomarkers for evaluating the prognosis of HBV-ACLF.
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