期刊
CURRENT ENVIRONMENTAL HEALTH REPORTS
卷 6, 期 3, 页码 73-79出版社
SPRINGERNATURE
DOI: 10.1007/s40572-019-00233-9
关键词
Environmental toxicants; Exosomes; Metals; Pesticides; Toxicity; Misfolded proteins; Neurotoxicity
资金
- National Institutes of Health [ES026892, ES019267, ES025991, NS088206]
- W. E. Lloyd Endowed Chair and Eminent Scholar in Veterinary Medicine and Armbrust Endowment
- Salisbury Endowed Chair
Purpose of ReviewThis review provides information regarding how exosomes may contribute to environmental chemical-induced pathogenesis of chronic diseases. In connecting exosome biology to environmental toxicology and disease pathogenesis, we address vital questions regarding what constitutes exosomal cargo, how toxicants influence exosomal cargo, and how environmental stimuli influence exosomal physiological and pathological functions.Recent FindingsRecent studies in the field demonstrate that exosomal cargo changes depending on external stimuli, which has consequences for the microenvironment of recipient cells.SummaryBased on recent findings, it is evident that exosomal cargo comprises various biological molecules including proteins, nucleic acids, and lipid molecules. Misfolded proteins and miRNA are examples of exosomal cargo molecules that can be altered by toxicants, ultimately changing the microenvironment of recipient cells in ways that are conducive to pathological processes. It will be crucial to map out the key signaling pathways that toxicants target to modulate exosomal cargo and their release.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据