期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 215, 期 2, 页码 521-535出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20170686
关键词
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资金
- National Natural Science Foundation of China [31400770, 81571186]
- 111 Project [B14036, B16021]
- National Basic Research Program of China (973 Program) [2014CB542205]
- Science & Technology Planning and Key Technology Innovation Projects of Guangdong [2014B050504006]
- Program for Changjiang Scholars and Innovative Research Team in University of Ministry of Education of China [IRT-15R13]
- Guangdong Innovative and Entrepreneurial Research Program [201301s0105240297]
Immune responses and neuroinflammation are critically involved in spinal cord injury (SCI).gamma delta T cells, a small subset of T cells, regulate the inflammation process in many diseases, yet their function in SCI is still poorly understood. In this paper, we demonstrate that mice deficient in gamma delta T cells (TCR delta(-/-)) showed improved functional recovery after SCI. gamma delta T cells are detected at the lesion sites within 24 hours after injury and are predominantly of the V gamma 4 subtype and express the inflammatory cytokine IFN-gamma. Inactivating IFN-gamma signaling in macrophages results in a significantly reduced production of proinflammatory cytokines in the cerebrospinal fluid (CSF) of mice with SCIs and improves functional recovery. Furthermore, treatment of SCI with anti-V gamma 4 antibodies has a beneficial effect, similar to that obtained with anti-TNF-alpha. In SCI patients, gamma delta T cells are detected in the CSF, and most of them are IFN-gamma positive. In conclusion, manipulation of gamma delta T cell functions may be a potential approach for future SCI treatment.
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