期刊
JOURNAL OF EXPERIMENTAL MEDICINE
卷 214, 期 5, 页码 1211-1226出版社
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20162014
关键词
-
资金
- Fundacao de Amparo a Pesquisa do Estado de Minas Gerais, Brazil [ETC-00154-16]
- Crohn's and Colitis Foundation of America
- Burroughs Wellcome Fund (PATH award)
- National Institutes of Health [R01 DK093674, R21 AI131188]
Tissue adaptation is an intrinsic component of immune cell development, influencing both resistance to pathogens and tolerance. Chronically stimulated surfaces of the body, in particular the gut mucosa, are the major sites where immune cells traffic and reside. Their adaptation to these environments requires constant discrimination between natural stimulation coming from harmless microbiota and food, and pathogens that need to be cleared. This review will focus on the adaptation of lymphocytes to the gut mucosa, a highly specialized environment that can help us understand the plasticity of leukocytes arriving at various tissue sites and how tissue-related factors operate to shape immune cell fate and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据