期刊
JOURNAL OF EXPERIMENTAL BOTANY
卷 69, 期 2, 页码 329-339出版社
OXFORD UNIV PRESS
DOI: 10.1093/jxb/erx254
关键词
Auxin; AuxRE; ARF; bZIP; bHLH; transcriptional regulation; chromatin states; bioinformatics
资金
- Russian Ministry of Science and Education under 5-100 Excellence Programme
- Russian State Budget [0324-2016-0008]
- Wageningen Graduate School
The phytohormone auxin regulates virtually every developmental process in land plants. This regulation is mediated via de-repression of DNA-binding auxin response factors (ARFs). ARFs bind TGTC-containing auxin response cis-elements (AuxREs), but there is growing evidence that additional cis-elements occur in auxin-responsive regulatory regions. The repertoire of auxin-related cis-elements and their involvement in different modes of auxin response are not yet known. Here we analyze the enrichment of nucleotide hexamers in upstream regions of auxin-responsive genes associated with auxin up-or down-regulation, with early or late response, ARF-binding domains, and with different chromatin states. Intriguingly, hexamers potentially bound by basic helix-loop-helix (bHLH) and basic leucine zipper (bZIP) factors as well as a family of A/T-rich hexamers are more highly enriched in auxin-responsive regions than canonical TGTC-containing AuxREs. We classify and annotate the whole spectrum of enriched hexamers and discuss their patterns of enrichment related to different modes of auxin response.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据