期刊
EPILEPSY & BEHAVIOR REPORTS
卷 12, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ebr.2019.100338
关键词
Seizures; Autoimmune encephalitis; Anti-NMDA receptor encephalitis; Demyelinating disease; Autoantibodies; Myelin oligodendrocyte glycoprotein
资金
- American Epilepsy Society Junior Investigator Research Award
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis, the most recognized type of autoimmune encephalitis, manifests with rapid cognitive dedine, psychosis, and seizures that develop in 78-86% of patients. Recently, anti-NMDAR encephalitis was reported in association with demyelinating diseases which are accompanied by a characteristic clinical phenotype, imaging abnormalities, and the presence of antibodies against myelin oligodendrocyte glycoprotein (MOG-IgG) in bodily fluids. The patient presented herein suffered from bilateral optic neuritis followed by recurrent encephalitis with focal seizures and demonstrated anti-NMDAR and MOG-IgGs in the cerebrospinal fluid and serum, respectively. Her symptoms responded to immuno-therapy and anti-seizure medication. The recognition of the novel syndrome of MOG antibody-associated demyelination (MOGAD), encompassing the overlapping anti-NMDAR encephalitis and other MOG-IgG associated disorders, is important for the successful management of these patients. (C) 2019 The Authors. Published by Elsevier Inc.
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