期刊
ADVANCED THERAPEUTICS
卷 2, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/adtp.201900144
关键词
animal studies; DNA-dense; nanostructure; origami; pharmaceutics; wireframe
资金
- Natural Science and Engineering Council of Canada (NSERC) [RGPIN-2015-04254, STPGP 493874]
- Tunisian Ministry of Education
- Fonds de Recherche du Quebec Nature et Technologies (FRQNT)
- Canadian Institutes for Health Research (CIHR)
- Chu Family Scholarship
DNA nanostructures are perfectly defined nanomaterials, and their shape/structure/surface chemistry (e.g., appended ligands) can be conveniently modulated by designing the sequence of their constituent DNA strands. No other natural or synthetic drug delivery system offers such predictability or modularity. As such, DNA nanostructures may provide exciting and potentially new opportunities for delivering drugs to diseased cell populations, or to specific sub-cellular compartments. To date, however, most studies have been performed in cell culture and only recently has the field advanced to in vivo testing. Considering how rapidly the field is evolving, this Progress Report surveys available studies involving the testing of DNA nanostructures in vivo, in an effort to elucidate trends and provide guidelines for future developments. This contribution presents the current progress toward characterizing the absorption, distribution, metabolism, elimination, and toxicity of DNA nanostructures.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据