期刊
JOURNAL OF EMERGENCY MEDICINE
卷 52, 期 2, 页码 E29-E31出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jemermed.2016.08.018
关键词
bone pain; emergency department; filgrastim; loratadine; Neupogen; Neulasta; pain control; pegfilgrastim
Background: Intractable bone pain is a notorious adverse effect of granulocyte-colony stimulating factors ( G-CSFs), such as pegfilgrastim and filgrastim, which are given to help prevent neutropenia in patients who are undergoing chemotherapy. G-CSF-induced bone pain is surprisingly common and often refractory to treatment with conventional analgesics. Case Report: This article describes an emergency department case of opiate and nonsteroidal anti-inflammatory drug-resistant pegfilgrastiminduced bone pain that was successfully alleviated with 10 mg of oral loratadine, allowing for discharge home. Why Should an Emergency Physician Be Aware of This?: This case suggests that loratadine may be an easy to implement, safe, and effective therapy in the emergency department management of intractable bone pain caused by G-CSF use. Emergency physicians should be aware that loratadine may successfully relieve otherwise intractable G-CSF-induced bone pain and allow for discharge home. (C) 2016 Elsevier Inc. All rights reserved.
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